Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsA downregulation of SNHG15 was observed in the ischemic hind limb of diabetic mice and high glucose-treated HUVECs.
[Laboratory Investigation]
6445218 X6AP8TGY items 1 apa 0 default asc 1 163192 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-3f7220b4006a469c7b4d06ea2b677234%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22X6AP8TGY%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhu%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhu%2C%20Q.%2C%20Lai%2C%20M.%2C%20Chen%2C%20T.%2C%20Wang%2C%20X.%2C%20Tian%2C%20L.%2C%20Li%2C%20D.%2C%20Wu%2C%20Z.%2C%20Wang%2C%20X.%2C%20He%2C%20Y.%2C%20He%2C%20Y.%2C%20Shang%2C%20T.%2C%20Xiang%2C%20Y.%2C%20%26amp%3B%20Zhang%2C%20H.%20%282021%29.%20LncRNA%20SNHG15%20relieves%20hyperglycemia-induced%20endothelial%20dysfunction%20via%20increased%20ubiquitination%20of%20thioredoxin-interacting%20protein.%20%3Ci%3ELaboratory%20Investigation%3C%5C%2Fi%3E%2C%201%26%23x2013%3B11.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41374-021-00614-5%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41374-021-00614-5%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DX6AP8TGY%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22LncRNA%20SNHG15%20relieves%20hyperglycemia-induced%20endothelial%20dysfunction%20via%20increased%20ubiquitination%20of%20thioredoxin-interacting%20protein%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian-qian%22%2C%22lastName%22%3A%22Zhu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ming-chun%22%2C%22lastName%22%3A%22Lai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tian-chi%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xun%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lu%22%2C%22lastName%22%3A%22Tian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dong-lin%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zi-heng%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiao-hui%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yun-yun%22%2C%22lastName%22%3A%22He%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yang-yan%22%2C%22lastName%22%3A%22He%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tao%22%2C%22lastName%22%3A%22Shang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi-lang%22%2C%22lastName%22%3A%22Xiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hong-kun%22%2C%22lastName%22%3A%22Zhang%22%7D%5D%2C%22abstractNote%22%3A%22Numerous%20studies%20have%20revealed%20that%20hyperglycemia%20is%20a%20pivotal%20driver%20of%20diabetic%20vascular%20complications.%20However%2C%20the%20mechanisms%20of%20hyperglycemia-induced%20endothelial%20dysfunction%20in%20diabetes%20remain%20incompletely%20understood.%20This%20study%20aims%20to%20expound%20on%20the%20underlying%20mechanism%20of%20the%20endothelial%20dysfunction%20induced%20by%20hyperglycemia%20from%20the%20perspective%20of%20long%20non-coding%20RNAs%20%28lncRNA%29.%20In%20this%20study%2C%20a%20downregulation%20of%20SNHG15%20was%20observed%20in%20the%20ischemic%20hind%20limb%20of%20diabetic%20mice%20and%20high%20glucose%20%28HG%29-treated%20HUVECs.%20Functionally%2C%20the%20overexpression%20of%20SNHG15%20promoted%20cell%20proliferation%2C%20migration%2C%20and%20tube%20formation%2C%20and%20suppressed%20cell%20apoptosis%20in%20HG-treated%20HUVECs.%20Mechanistically%2C%20SNHG15%20reduced%20thioredoxin-interacting%20protein%20%28TXNIP%29%20expression%20by%20enhancing%20ITCH-mediated%20ubiquitination%20of%20TXNIP.%20TXNIP%20overexpression%20abrogated%20the%20protective%20effect%20of%20lncRNA%20SNHG15%20overexpression%20on%20HG-induced%20endothelial%20dysfunction.%20The%20following%20experiment%20further%20confirmed%20that%20SNHG15%20overexpression%20promoted%20angiogenesis%20of%20the%20ischemic%20hind%20limb%20in%20diabetic%20mice.%20In%20conclusion%2C%20SNHG15%20is%20a%20novel%20protector%20for%20hyperglycemia-induced%20endothelial%20dysfunction%20via%20decreasing%20TXNIP%20expression.%22%2C%22date%22%3A%222021-06-08%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41374-021-00614-5%22%2C%22ISSN%22%3A%221530-0307%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41374-021-00614-5%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-08T18%3A24%3A19Z%22%7D%7D%5D%7D
Zhu, Q., Lai, M., Chen, T., Wang, X., Tian, L., Li, D., Wu, Z., Wang, X., He, Y., He, Y., Shang, T., Xiang, Y., & Zhang, H. (2021). LncRNA SNHG15 relieves hyperglycemia-induced endothelial dysfunction via increased ubiquitination of thioredoxin-interacting protein. Laboratory Investigation, 1–11. https://doi.org/10.1038/s41374-021-00614-5 Cite
