Scientists review the current knowledge and crucial information about how SARS-CoV-2 attaches on the surface of host cells through a variety of receptors, such as ACE2, neuropilin-1, AXL, and antibody–FcγR complexes.
[Signal Transduction and Targeted Therapy]
6445218 QVWXFV5C items 1 apa 0 default asc 1 163356 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-aae63e6005af36d70502383ad8ec6db5%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22QVWXFV5C%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhang%2C%20Q.%2C%20Xiang%2C%20R.%2C%20Huo%2C%20S.%2C%20Zhou%2C%20Y.%2C%20Jiang%2C%20S.%2C%20Wang%2C%20Q.%2C%20%26amp%3B%20Yu%2C%20F.%20%282021%29.%20Molecular%20mechanism%20of%20interaction%20between%20SARS-CoV-2%20and%20host%20cells%20and%20interventional%20therapy.%20%3Ci%3ESignal%20Transduction%20and%20Targeted%20Therapy%3C%5C%2Fi%3E%2C%20%3Ci%3E6%3C%5C%2Fi%3E%281%29%2C%201%26%23x2013%3B19.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41392-021-00653-w%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41392-021-00653-w%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DQVWXFV5C%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Molecular%20mechanism%20of%20interaction%20between%20SARS-CoV-2%20and%20host%20cells%20and%20interventional%20therapy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qianqian%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rong%22%2C%22lastName%22%3A%22Xiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shanshan%22%2C%22lastName%22%3A%22Huo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yunjiao%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shibo%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiao%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fei%22%2C%22lastName%22%3A%22Yu%22%7D%5D%2C%22abstractNote%22%3A%22The%20pandemic%20of%20coronavirus%20disease%202019%20%28COVID-19%29%20caused%20by%20severe%20acute%20respiratory%20syndrome%20coronavirus%202%20%28SARS-CoV-2%29%20infection%20has%20resulted%20in%20an%20unprecedented%20setback%20for%20global%20economy%20and%20health.%20SARS-CoV-2%20has%20an%20exceptionally%20high%20level%20of%20transmissibility%20and%20extremely%20broad%20tissue%20tropism.%20However%2C%20the%20underlying%20molecular%20mechanism%20responsible%20for%20sustaining%20this%20degree%20of%20virulence%20remains%20largely%20unexplored.%20In%20this%20article%2C%20we%20review%20the%20current%20knowledge%20and%20crucial%20information%20about%20how%20SARS-CoV-2%20attaches%20on%20the%20surface%20of%20host%20cells%20through%20a%20variety%20of%20receptors%2C%20such%20as%20ACE2%2C%20neuropilin-1%2C%20AXL%2C%20and%20antibody%5Cu2013Fc%5Cu03b3R%20complexes.%20We%20further%20explain%20how%20its%20spike%20%28S%29%20protein%20undergoes%20conformational%20transition%20from%20prefusion%20to%20postfusion%20with%20the%20help%20of%20proteases%20like%20furin%2C%20TMPRSS2%2C%20and%20cathepsins.%20We%20then%20review%20the%20ongoing%20experimental%20studies%20and%20clinical%20trials%20of%20antibodies%2C%20peptides%2C%20or%20small-molecule%20compounds%20with%20anti-SARS-CoV-2%20activity%2C%20and%20discuss%20how%20these%20antiviral%20therapies%20targeting%20host%5Cu2013pathogen%20interaction%20could%20potentially%20suppress%20viral%20attachment%2C%20reduce%20the%20exposure%20of%20fusion%20peptide%20to%20curtail%20membrane%20fusion%20and%20block%20the%20formation%20of%20six-helix%20bundle%20%286-HB%29%20fusion%20core.%20Finally%2C%20the%20specter%20of%20rapidly%20emerging%20SARS-CoV-2%20variants%20deserves%20a%20serious%20review%20of%20broad-spectrum%20drugs%20or%20vaccines%20for%20long-term%20prevention%20and%20control%20of%20COVID-19%20in%20the%20future.%22%2C%22date%22%3A%222021-06-11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41392-021-00653-w%22%2C%22ISSN%22%3A%222059-3635%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41392-021-00653-w%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-11T22%3A18%3A55Z%22%7D%7D%5D%7D
Zhang, Q., Xiang, R., Huo, S., Zhou, Y., Jiang, S., Wang, Q., & Yu, F. (2021). Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy. Signal Transduction and Targeted Therapy, 6(1), 1–19. https://doi.org/10.1038/s41392-021-00653-w Cite