Impaired Regulation of Heart Rate and Sinoatrial Node Function by the Parasympathetic Nervous System in Type 2 Diabetic Mice

Using type 2 diabetic db/db mice in vivo and isolated sinoatrial node (SAN) myocytes, scientists investigated whether blunted parasympathetic nervous system (PNS) effects on HR in type 2 diabetes mellitus were related to impaired responsiveness of the SAN to PNS agonists.