Arginine Methylation of METTL14 Promotes RNA N6-Methyladenosine Modification and Endoderm Differentiation of Mouse Embryonic Stem Cells

The authors investigated the role of methylation of the core methyltransferase METTL3/METTL14 in m6A regulation. They found that global mRNA m6A levels were greatly decreased in METTL14 R255K mutant mouse ESCs (mESCs) and that that loss of R255me preferentially affected endoderm differentiation in mESCs.