Sr–CPHC facilitated the migration and tube formation of human umbilical vein endothelial cells in vitro and up-regulated the expression of the vascular endothelial growth factor and Angiopoietin-1.
[Journal of Materials Chemistry B]
6445218 LNXFA7CE items 1 apa 0 default asc 1 163627 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-8592b3c3f88a801982b99fabae53b026%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22LNXFA7CE%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wu%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-25%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWu%2C%20X.%2C%20Tang%2C%20Z.%2C%20Wu%2C%20K.%2C%20Bai%2C%20Y.%2C%20Lin%2C%20X.%2C%20Yang%2C%20H.%2C%20Yang%2C%20Q.%2C%20Wang%2C%20Z.%2C%20Ni%2C%20X.%2C%20Liu%2C%20H.%2C%20%26amp%3B%20Yang%2C%20L.%20%282021%29.%20Strontium%26%23x2013%3Bcalcium%20phosphate%20hybrid%20cement%20with%20enhanced%20osteogenic%20and%20angiogenic%20properties%20for%20vascularised%20bone%20regeneration.%20%3Ci%3EJournal%20of%20Materials%20Chemistry%20B%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2FD1TB00439E%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2FD1TB00439E%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DLNXFA7CE%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Strontium%5Cu2013calcium%20phosphate%20hybrid%20cement%20with%20enhanced%20osteogenic%20and%20angiogenic%20properties%20for%20vascularised%20bone%20regeneration%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiexing%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ziniu%22%2C%22lastName%22%3A%22Tang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kang%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanjie%22%2C%22lastName%22%3A%22Bai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiao%22%2C%22lastName%22%3A%22Lin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huilin%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiang%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zheng%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xinye%22%2C%22lastName%22%3A%22Ni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huiling%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lei%22%2C%22lastName%22%3A%22Yang%22%7D%5D%2C%22abstractNote%22%3A%22Vascularized%20bone%20tissue%20engineering%20is%20regarded%20as%20one%20of%20the%20optimal%20treatment%20options%20for%20large%20bone%20defects.%20The%20lack%20of%20angiogenic%20properties%20and%20unsatisfactory%20physicochemical%20performance%20restricts%20calcium%20phosphate%20cement%20%28CPC%29%20from%20application%20in%20vascularized%20bone%20tissue%20engineering.%20Our%20previous%20studies%20have%20developed%20a%20starch%20and%20BaSO4%20incorporated%20calcium%20phosphate%20hybrid%20cement%20%28CPHC%29%20with%20improved%20mechanical%20strength%20and%20handling%20properties.%20However%2C%20the%20bioactivity%5Cu2014especially%20the%20angiogenic%20ability%5Cu2014is%20still%20absent%20and%20requires%20further%20improvement.%20Herein%2C%20based%20on%20the%20reported%20CPHC%20and%20the%20osteogenic%20and%20angiogenic%20properties%20of%20strontium%20%28Sr%29%20ions%2C%20a%20strontium-enhanced%20calcium%20phosphate%20hybrid%20cement%20%28Sr%5Cu2013CPHC%29%20was%20developed%20to%20improve%20both%20biological%20and%20physicochemical%20properties%20of%20CPC.%20Compared%20to%20CPC%2C%20the%20initial%20setting%20time%20of%20Sr%5Cu2013CPHC%20was%20prolonged%20from%202.2%20min%20to%2020.7%20min.%20The%20compressive%20strength%20of%20Sr%5Cu2013CPHC%20improved%20from%2011.21%20MPa%20to%2045.52%20MPa%20compared%20with%20CPC%20as%20well.%20Sr%5Cu2013CPHC%20was%20biocompatible%20and%20showed%20promotion%20of%20alkaline%20phosphatase%20%28ALP%29%20activity%2C%20calcium%20nodule%20formation%20and%20osteogenic%20relative%20gene%20expression%2C%20suggesting%20high%20osteogenic-inductivity.%20Sr%5Cu2013CPHC%20also%20facilitated%20the%20migration%20and%20tube%20formation%20of%20human%20umbilical%20vein%20endothelial%20cells%20%28HUVECs%29%20in%20vitro%20and%20up-regulated%20the%20expression%20of%20the%20vascular%20endothelial%20growth%20factor%20%28VEGF%29%20and%20Angiopoietin-1%20%28Ang-1%29.%20In%20vivo%20evaluation%20showed%20marked%20new%20bone%20formation%20in%20a%20rat%20calvarial%20defect%20model%20with%20Sr-CPHC%20implanted.%20Sr%5Cu2013CPHC%20also%20exhibited%20enhancement%20of%20neovascularization%20in%20subcutaneous%20connective%20tissue%20in%20a%20rat%20subcutaneous%20implantation%20model.%20Thus%2C%20the%20Sr%5Cu2013CPHC%20with%20the%20dual%20effects%20of%20osteogenesis%20and%20angiogenesis%20shows%20great%20potential%20for%20clinical%20applications%20such%20as%20the%20repair%20of%20ischemic%20osteonecrosis%20and%20critical-size%20bone%20defects.%22%2C%22date%22%3A%222021-05-25%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1039%5C%2FD1TB00439E%22%2C%22ISSN%22%3A%222050-7518%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubs.rsc.org%5C%2Fen%5C%2Fcontent%5C%2Farticlelanding%5C%2F2021%5C%2Ftb%5C%2Fd1tb00439e%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-18T21%3A32%3A13Z%22%7D%7D%5D%7D
Wu, X., Tang, Z., Wu, K., Bai, Y., Lin, X., Yang, H., Yang, Q., Wang, Z., Ni, X., Liu, H., & Yang, L. (2021). Strontium–calcium phosphate hybrid cement with enhanced osteogenic and angiogenic properties for vascularised bone regeneration. Journal of Materials Chemistry B. https://doi.org/10.1039/D1TB00439E Cite