Ultrapotent Miniproteins Targeting the SARS-CoV-2 Receptor-Binding Domain Protect against Infection and Disease

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Scientists investigated the capacity of modified versions of one lead miniprotein, LCB1, to protect against SARS-CoV-2-mediated lung disease in mice.
[Cell Host & Microbe]
Case, J. B., Chen, R. E., Cao, L., Ying, B., Winkler, E. S., Johnson, M., Goreshnik, I., Pham, M. N., Shrihari, S., Kafai, N. M., Bailey, A. L., Xie, X., Shi, P.-Y., Ravichandran, R., Carter, L., Stewart, L., Baker, D., & Diamond, M. S. (2021). Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease. Cell Host & Microbe, 0(0). https://doi.org/10.1016/j.chom.2021.06.008 Cite
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