Targeted Intracellular Delivery of Trastuzumab Using Designer Phage lambda Nanoparticles Alters Cellular Programs in Human Breast Cancer Cells

Trastuzumab-phage-like particles bound to the oncogenically active human epidermal growth factor receptor 2 (HER2) and were internalized by breast cancer cells of the HER2 overexpression subtype, but not by those lacking the HER2 amplification.