p53 Convergently Activates Dux/DUX4 in Embryonic Stem Cells and in Facioscapulohumeral Muscular Dystrophy Cell Models

p53 activation convergently evolved to couple p53 to double homeobox (Dux)/DUX4 activation in ESCs, embryos and cells from patients with facioscapulohumeral muscular dystrophy (FSHD), potentially uniting the developmental and disease regulation of DUX-family factors and identifying evidence-based therapeutic opportunities for FSHD.