Silencing the G-Protein Coupled Receptor 3-Salt Inducible Kinase 2 Pathway Promotes Human β Cell Proliferation

Investigators reported the development of a high-throughput RNAi screening approach to identify upstream pathways that regulated adult human β cell quiescence and demonstrated in a screen of the GPCRome that silencing G-protein coupled receptor 3 (GPR3) led to human pancreatic β cell proliferation.