Driving Regeneration, Instead of Healing, in Adult Mammals: The Decisive Role of Resident Macrophages through Efferocytosis

By using studies of gain and loss of function, specific cell depletion approaches, and hematopoietic chimeras researchers demonstrated that tissue regeneration in adult mammals depends on an early and transient peak of granulocyte producing reactive oxygen species and an efficient efferocytosis specifically by tissue-resident macrophages.