ASCL1, NKX2-1, and PROX1 Co-Regulate Subtype-Specific Genes in Small Cell Lung Cancer

The authors integrated chromatin landscape and transcriptome analyses of patient-derived small cell lung cancer (SCLC) preclinical models to identify super-enhancers and their associated genes in the ASCL1-, NEUROD1-, and POU2F3-high SCLC subtypes.