The Acute Phase Protein Lactoferrin Is a Key Feature of Alzheimer’s Disease and Predictor of Aβ Burden through Induction of APP Amyloidogenic Processing

In vitro studies showed that an interaction between amyloid precursor protein (APP) and the iron-bound form of lactoferrin secreted from activated microglia diverted neuronal APP endocytosis from the canonical clathrin-dependent pathway to one requiring ADP ribosylation factor 6 trafficking.