EPS8 Supports Pancreatic Cancer Growth by Inhibiting BMI1 Mediated Proteasomal Degradation of ALDH7A1

Researchers explored the interplay between epidermal growth factor receptor kinase substrate 8 and aldehyde dehydrogenase 7 family member A1 (ALDH7A1) in pancreatic ductal adenocarcinoma (PADC) cells. PADC cell lines MIA PaCa-2 and AsPANC-1 were used for in vitro and in vivo studies.