CRISPR/Cas9 Correction of OPA1 c.1334G>A: p.R445H Restores Mitochondrial Homeostasis in Dominant Optic Atrophy Patient-Derived iPSCs

Researchers demonstrated generation of patient-derived OPA1 c.1334G>A: p.R445H mutant iPSCs, followed by correction of OPA1 through CRISPR/Cas9 guided homology directed repair and evaluated the effect of OPA1 correction on mitochondrial homeostasis.