Signaling Profiles in HEK 293T Cells Co-Expressing GLP-1 and GIP Receptors

Scientists showed that when the two receptors were co-expressed in HEK 293T cells with comparable receptor ratio to pancreatic cancer cells, glucose-dependent insulinotropic polypeptide (GIP) predominately induced cAMP accumulation while Glucagon-like peptide-1 (GLP-1) was biased towards β-arrestin 2 recruitment.