Anti-Latent TGFβ Binding Protein 4 Antibody Improves Muscle Function and Reduces Muscle Fibrosis in Muscular Dystrophy

Scientists generated a monoclonal human anti-latent transforming growth factor β binding protein 4 (LTBP4) antibody directed toward LTBP4’s hinge region. In vitro, anti-LTBP4 bound LTBP4 protein and reduced LTBP4 proteolytic cleavage. In isolated myofibers, the LTBP4 antibody stabilized the sarcolemma from injury.