TCF/LEF Regulation of the Topologically Associated Domain ADI Promotes mESCs to Exit the Pluripotent Ground State

The authors found that genetic deletion of the four genes encoding the TCF/LEF transcription factors confered mouse ESCs (mESCs) with the ability to self-renew in N2B27 medium alone, identifying TCF/LEF effectors that mediated exit from the pluripotent state.