Malat-1-PRC2-EZH1 Interaction Supports Adaptive Oxidative Stress Dependent Epigenome Remodeling in Skeletal Myotubes

Investigators studied terminally differentiated postmitotic skeletal muscle cells in which oxidative stress induced the dynamic activation of PRC2-Ezh1 through Embryonic Ectoderm Develpment shuttling to the nucleus and identified lncRNA Malat-1 as a necessary partner for PRC2-Ezh1-dependent response to oxidative stress.