Protective CD4+ Th1 Cell-Mediated Immunity Is Reliant upon Execution of Effector Function Prior to the Establishment of the Pathogen Niche

The authors reported that CXCR3-dependent recruitment of Ly6C+ Th1 effector cells was indispensable for concomitant immunity and acute cell-phagocyte interactions were critical to prevent the establishment of a permissive pathogen niche.