Mutational Synergy during Leukemia Induction Remodels Chromatin Accessibility, Histone Modifications and Three-Dimensional DNA Topology to Alter Gene Expression

Researchers applied an integrated genomic approach to a murine allelic series that modeled the two most common mutations in acute myeloid leukemia (AML): Flt3-ITD and Npm1c, then deconvoluted the contribution of each mutation to alterations of the epigenetic landscape and genome organization.