BTK Operates a Phospho-Tyrosine Switch to Regulate NLRP3 Inflammasome Activity

Scientists showed that a well-established drug target, Bruton’s tyrosine kinase, affected several levels of NLRP3 regulation. BTK directly interacted with NLRP3 in immune cells and phosphorylates four conserved tyrosine residues upon inflammasome activation, in vitro and in vivo.