Development and Characterization of a DNA Aptamer for MLL-AF9 Expressing Acute Myeloid Leukemia Cells Using Whole Cell-SELEX

Aptamers were selected against acute myeloid leukemia cells expressing the MLL-AF9 oncogene through systematic evolution of ligands by exponential enrichment (SELEX). Twelve rounds of SELEX, including two counter selections against fibroblast cells, were completed.