Aberrantly Reduced Expression of miR-342-5p Contributes to CCND1-Associated Chronic Myeloid Leukemia Progression and Imatinib Resistance

Scientists used next-generation sequencing to explore endogenous miRNAs in chronic myeloid leukemia (CML) patients versus healthy volunteers, and miR-342-5p was identified as the primary target. They found that miR-342-5p was downregulated in CML patients and had a significant inhibitory effect on cell proliferation in CML.