L1CAM Promotes Ovarian Cancer Stemness and Tumor Initiation via FGFR1/SRC/STAT3 Signaling

The genetic manipulation of L1CAM in ovarian carcinoma (OC) cells provided gain and loss-of-function models that were then employed in cell biological assays as well as in vivo tumorigenesis experiments to assess the role of L1CAM in OC cell stemness and in ovarian OSC-driven tumor initiation.