NRG1 and NRG2 Fusions in Non-small Cell Lung Cancer (NSCLC): Seven Years between Lights and Shadows

Fusions in neuregulin 1 (NRG1) and neuregulin 2 (NRG2) genes are molecular features of non-small cell lung cancer. These rearrangements enhance ectopic expression of the NRG/ErbB receptor‐ligand and induce the triggering of downstream pathways.