SARS-CoV-2 B.1.1.7 (Alpha) and B.1.351 (Beta) Variants Induce Pathogenic Patterns in K18-hACE2 Transgenic Mice Distinct from Early Strains

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Investigators demonstrated in K18-hACE2 transgenic mice that B.1.1.7 and B.1.351 were 100-fold more lethal than the original SARS-CoV-2 bearing 614D.
[Nature Communications]

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