Common Cardiac Medications Potently Inhibit ACE2 Binding to the SARS-CoV-2 Spike, and Block Virus Penetration and Infectivity in Human Lung Cells

Researchers found that ouabain, digitoxin and digoxin blocked penetration by SARS-CoV-2 Spike-pseudotyped virus into human lung cells, and infectivity by native SARS-CoV-2.