Disparate Effects of MMP and TIMP Modulation on Coronary Atherosclerosis and Associated Myocardial Fibrosis

The contribution of select matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) to the progression of myocardial infarction and progressive sudden death was examined in Apoe-deficient mice with concomitant deletion of Mmp7, Mmp9, Mmp12, or Timp1 and relevant wild-type controls after 36-weeks high-fat feeding.