HIF1α/HIF2α Induces Glioma Cell Dedifferentiation into Cancer Stem Cells through Sox2 under Hypoxic Conditions

Scientists performed a series of experiments to verify whether HIF1α, HIF2α and Sox2 regulated glioma cell dedifferentiation under hypoxic conditions. Sphere formation by single glioma cells was observed, and CD133 and CD15 expression was compared between the normoxic and hypoxic groups.