PLOD3 Regulates the Expression of YAP1 to Affect the Progression of Non-Small Cell Lung Cancer via the PKCδ/CDK1/LIMD1 Signaling Pathway

Silencing procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD3) promoted the cleavage ofprotein kinase C δ (PKCδ) in a caspase-dependent manner to generate a catalytically active fragment cleaved PKCδ, enhanced phosphorylation levels of CDK1, and LIMD1 but suppressed nuclear translocation of YAP1.