Sirtuin-1 – Mediated NF-κB Pathway Modulation to Mitigate Inflammasome Signaling and Cellular Apoptosis Is One of the Neuroprotective Effects of Intra-arterial Mesenchymal Stem Cell Therapy Following Ischemic Stroke

The authors unveiled the role of MSCs in regulating the brain sirtuin-1 (SIRT-1) levels following stroke and the involvement of SIRT-1 in regulating inflammasome signaling to reduce cellular apoptosis towards rendering neuroprotection.