BCL-XL Inhibition Induces an FGFR4-Mediated Rescue Response in Colorectal Cancer

Scientists screened a compound library for synergy with low-dose BCL-XL inhibitor A-1155463 to identify pathways that regulated sensitivity to BCL-XL inhibition and revealed that fibroblast growth factor receptor (FGFR)4 inhibition effectively sensitizes to A-1155463 both in vitro and in vivo.