Modeling iPSC-Derived Human Neurofibroma-Like Tumors in Mice Uncovers the Heterogeneity of Schwann Cells within Plexiform Neurofibromas

The authors developed an iPSC-based neural crest-Schwann cell in vitro differentiation system and constructed a lineage expression roadmap for the analysis of different 2D and 3D neurofibroma models.