PLP2-Derived Peptide Rb4 Triggers PARP-1-Mediated Necrotic Death in Murine Melanoma Cells

Researchers studied the antitumor activity of peptide Rb4 derived from Proteolipid protein 2 (PLP2). In vitro, Rb4 induced F-actin polymerization, prevented F-actin depolymerization and increased the ER-derived cytosolic calcium.