Characterization of Disease-Propagating Stem Cells Responsible for Myeloproliferative Neoplasm-Blast Phase

Researchers showed that myeloproliferative neoplasm (MPN)-blast phase (BP) initiating cells originated from not only phenotypically identified hematopoietic stem cells but also lymphoid-myeloid progenitor cells which were each characterized by differences in MPN-BP initiating activity and self-renewal capacity.