Urokinase Plasminogen Activator Induces Epithelial-Mesenchymal and Metastasis of Pancreatic Cancer Through Plasmin/MMP14/TGF-β Axis, Which Is Inhibited by 4-Acetyl-Antroquinonol B Treatment

Researchers employed MiaPaCa-2 and PANC-1 cell lines and investigated how urokinase-plasmin activator (uPA) regulated epithelial-mesenchymal transition and metastasis in pancreatic cancer, and presented a novel approach aimed at inhibiting uPA in pancreatic cancer.