β-Cell-Specific Deletion of PFKFB3 Restores Cell Fitness Competition and Physiological Replication under Diabetogenic Stress

To discriminate the role of PFKFB3 from HIF1α in vivo, scientists generated mice with conditional β-cell specific disruption of the Pfkfb3 gene on a human islet pancreatic polypeptide background and a high-fat diet.