Lipase-Triggered Drug Release from BCL2 Inhibitor ABT-199-Loaded Nanoparticles to Elevate Anti-leukemic Activity through Enhanced Drug Targeting on the Mitochondrial Membrane

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Researchers compared the anti-leukemic ability of pure ABT-199 and PEG-ABT-199 in vitro and in vivo.
[Acta Biomaterialia]
AbstractGraphical Abstract