Keep Current with the Latest in Cell Biology Research

Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage Ambiguous Stem Cell Leukemia

The authors described a distinct subgroup of acute leukemia with expression of myeloid, T lymphoid and stem cell markers driven by aberrant allele-specific deregulation of BCL11B, a master transcription factor responsible for thymic T-lineage commitment and specification.
[Cancer Discovery]
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Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Production of Suppressive Myeloid Cells from Human Hematopoietic Progenitor Cells In Vitro

To examine the ontogeny and function of MS1 cells, scientists developed a cellular model for inducing CD14+ MS1 monocytes by treating human hematopoietic stem and progenitor cells from healthy bone marrow donors in culture with plasma from patients with severe bacterial infection or SARS-CoV-2 infection.
[Science Translational Medicine]
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Biologic Assignment Trial of Reduced-Intensity Hematopoietic Cell Transplantation Based on Donor Availability in Patients 50–75 Years of Age with Advanced Myelodysplastic Syndrome

Investigators conducted a multicenter biologic assignment trial comparing reduced-intensity hematopoietic cell transplantation to hypomethylating therapy or best supportive care in subjects 50-75 years of age with intermediate-2 or high-risk de novo myelodysplastic syndromes.
[Journal of Clinical Oncology]
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Association of Diet Quality with Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events

Researchers conducted a cohort study to examine whether there was an association between diet quality and the prevalence of clonal hematopoiesis of indeterminate potential.
[JAMA Cardiology]
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Fanconi Anemia Proteins Participate in a Break-Induced-Replication-Like Pathway to Counter Replication Stress

Scientists showed that Fanconi anemia (FA)-mutated cells were hypersensitive to persistent replication stress and that FA proteins played a role in the break-induced-replication-like pathway for fork restart.
[Nature Structural & Molecular Biology]
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Targeted PI3K/AKT-Hyperactivation Induces Cell Death in Chronic Lymphocytic Leukemia

Scientists hypothesized that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT (PI3K/AKT)-signaling pathway may have been leveraged to trigger chronic lymphocytic leukemia cell death.
[Nature Communications]
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Interrogation of Novel CDK2/9 Inhibitor Fadraciclib (CYC065) as a Potential Therapeutic Approach for AML

In AML cell lines, myeloid cell leukemia 1 was downregulated following treatment with fadraciclib, resulting in a rapid induction of apoptosis.
[Cell Death Discovery]
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Cabozantinib Promotes Erythroid Differentiation in K562 Erythroleukemia Cells through Global Changes in Gene Expression and JNK Activation

The authors reported that cabozantinib could promote differentiation in erythroid leukemia cells and found that K562 erythroid leukemia cells treated with 1 μM cabozantinib for 72 hours underwent erythroid lineage differentiation.
[Cancer Gene Therapy]
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Longitudinal Single-Cell Dynamics of Chromatin Accessibility and Mitochondrial Mutations in Chronic Lymphocytic Leukemia Mirror Disease History

Researchers employed mitochondrial single-cell assay for transposase-accessible chromatin with sequencing to profile 163,279 cells from nine patients with chronic lymphocytic leukemia collected across disease course and utilized mitochondrial DNA mutations as natural genetic markers of cancer clones.
[Cancer Discovery]
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Depalmitoylation Rewires FLT3-ITD Signaling and Exacerbates Leukemia Progression

Investigators discovered that FLT3-ITD, one of the most frequent mutations in acute myeloid leukemia, was S-palmitoylated by the ZDHHC6 palmitoyl acyltransferase. Disruption of palmitoylation redirected FLT3-ITD to the plasma membrane and rewired its downstream signaling by activating AKT and ERK pathways in addition to STAT5.
[Blood]
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Non-Conditioned Bone Marrow Chimeric Mouse Generation Using Culture-Based Enrichment of Hematopoietic Stem and Progenitor Cells

The authors described their development of cell culture techniques for the enrichment of functional hematopoietic stem and progenitor cells from mouse bone marrow without the use of fluorescence-activated cell sorting purification.
[Nature Communications]
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