Molecular Phenotyping Reveals the Identity of Barrett’s Esophagus and Its Malignant Transition

A combination of single-cell transcriptomic profiling, in silico lineage tracing from methylation, open chromatin and somatic mutation analyses, and functional studies in organoid models showed that Barrett’s esophagus originated from gastric cardia through c-MYC and HNF4A-driven transcriptional programs.