[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.

[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.

[Nature Biotechnology] Investigators engineered an Acidaminococcus Cas12a (AsCas12a) variant, multiplexed transcriptional interference AsCas12a, that incorporated R1226A, a mutation that stabilized the ribonucleoprotein–DNA complex via DNA nicking.

[Communications Biology] Investigators showed that PRMT5 directly methylated STAT3 and enhances its activated tyrosine phosphorylation in non-small cell lung cancer cells.

Scientists explored the mechanism of fluoride interference in the immune system and also identify the key indicators of fluoride-induced immune damage. [Human Reproduction] AbstractGraphical Abstract

Researchers investigated whether and how bevacizumab regulated ferroptosis and immune activity in liver cancer. They performed RNA-sequencing in bevacizumab-treated human liver cancer cell line...

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists deciphered a mechanism that enabled the proliferation and differentiation of satellite cells through the downregulation of trans-2,3-enoyl-CoA reductase like (TECRL) during muscle regeneration.

[Stem Cell Research & Therapy] The authors provide a brief overview of erythropoiesis and examine endeavors to recapitulate erythropoiesis in vitro using various cell sources.

[Journal of Translational Medicine] The authors evaluated the feasibility of intraperitoneal administration of non-virally engineered MSCs to co-deliver cytosine deaminase and uracil phosphoribosyl transferase/5-Flucytosine prodrug system and interferon-beta to potentially enhance the cGAS-STING signaling axis.

[Development] Investigators showed that, in contrast to prior reports, bone morphogenic protein signaling (SMAD1/5/9 phosphorylation) is not detectable until implantation when it is detected in the primitive endoderm – an extraembryonic lineage.

[Journal of Genetics and Genomics] Scientists showed that GPR160, a class A member of G protein-coupled receptors, was dramatically downregulated concurrent with mESC differentiation into embryoid bodies in vitro.