[Journal of Materials Chemistry B] Scientists presented a skin-derived ECM–based platform that leverages its inherent biocompatibility and cell affinity for efficient nitric oxide delivery.

[Ocular Therapeutix] Ocular Therapeutix announced the successful completion of its Pre-New Drug Application Meeting with the U.S. Food and Drug Administration (FDA) for its investigational product candidate AXPAXLI™ (also known as OTX-TKI) for the treatment of wet age-related macular degeneration (wet AMD).

[Signal Transduction and Targeted Therapy] Scientists investigated whether transcriptional pause release and RNA polymerase II elongation constitute an early regulatory layer that promotes endothelial-to-mesenchymal transition and atherosclerosis.

[Cardiovascular Research] Using circRNA microarray sequencing, the authors identified circILRUN as the most markedly upregulated circRNA in small extracellular vesicles from oscillatory shear stress-stimulated human valvular endothelial cells.

[Advanced Healthcare Materials] Researchers developed a nanozyme system that targets E-selectin on inflamed endothelium and is capable of halting excessive ROS accumulation within the critical therapeutic time window in acute lung injury.

[Nature Cardiovascular Research] Investigators showed that aging reduces cardiac lymphatic vessel density in humans and mice and induces structural remodeling characterized by tighter, zipper-like endothelial junctions.

[Acta Biomaterialia] The authors hypothesized that mesoscale surface geometry could preserve endothelial coverage and function under extreme shear. Engineered microtrenches were introduced onto an implant biomaterial to generate spatially defined shear environments.

[Science Signaling] Scientists used proximity proteomics to identify components of the receptor activity–modifying protein 3 (RAMP3) interactome that regulated calcitonin receptor-like receptor (CLR) and characterized how the interactome changed in response to the prolymphangiogenic peptide adrenomedullin.

[Archivos De Bronconeumologia] Researchers analyzed endothelial colony-forming cells derived from pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension patients and healthy-controls to identify disease-specific molecular and functional alterations.

[Archives of Toxicology] Investigators combined a propensity score-matched nationwide cohort of 28,802 patients with experiments in primary human endothelial progenitor cells and zebrafish embryos to study the effects of clozapine on endothelial repair and potential relevance to coronary artery disease.

[American Journal of Ophthalmology] The authors discuss recent advances in corneal endothelial cell therapy, tissue engineering, gene- and RNA-targeted approaches, and pharmacologic therapies aimed at preserving or replacing the corneal endothelium.

[Life Sciences] Scientists summarize the current understanding of endothelial-to-mesenchymal transition in ischemic diseases, focusing on the major regulatory signaling pathways and epigenetic mechanisms.