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[Molecular Therapy] Investigators demonstrated successful production of helper-dependent adenoviral vectors expressing an all-in-one base editor mapping to the sickle mutation site. In HSC-enriched cells from sickle cell disease patients, transduction with the base editing vector in vitro resulted in 35% GTG to GCG conversion and phenotypic improvements of derived red blood cells.

[Trends In Cell Biology] Scientists explore how differential glycosylation in cancer influences the metabolism and stemness features alongside new avenues in glycobiology.

[iScience] Investigators attempted to investigate the underlying mechanism of SLFN4+ myeloid-derived suppressor cells in affecting gastric intestinal metaplasia.

[Nature News] People who have received transplants for blood cancer, some more than 40 years ago, do not have high rates of potentially cancer-causing mutations.

[EMBO Reports] The authors profile orphan G protein-coupled receptors in the dorsal root ganglia following tumor infiltration, and observe a notable increase in GPR160 expression. Elevated Gpr160 mRNA and protein levels persist from postoperative day 6 for over 18 days in the affected DRG, predominantly in small-diameter C-fiber type neurons specific to the tibia.

[ACS Nano] The authors demonstrated that in utero intracerebroventricular injection of densely PEGylated lipid nanoparticles containing an acid-degradable PEG–lipid could safely and effectively deliver mRNA for gene editing enzymes to the fetal mouse brain, resulting in successful transfection and editing of brain cells.