The authors performed an in silico study of ADAMTS1 and endothelial markers in human gliomas, providing the basis to further assess these molecules in several primary glioblastoma-initiating cells and established glioblastoma cells with the ability to acquire an endothelial-like phenotype.
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Investigators report a fucoidan-decorated silica-carbon nano-onion hybrid nanoparticle that targeted tumor vasculature to specifically release P-glycoprotein inhibitor and anticancer drug into tumor cells.
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Wang, H., Liang, Y., Yin, Y., Zhang, J., Su, W., White, A. M., Bin Jiang, Xu, J., Zhang, Y., Stewart, S., Lu, X., & He, X. (2021). Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance. Nature Communications, 12(1), 312. https://doi.org/10.1038/s41467-020-20588-0 Cite
The authors investigated changes of the vascular smooth muscle cell (VSMC) transcriptome by utilizing 3D human vascular organoids organized as a core of VSMCs enclosed by a monolayer of endothelial cells.
[Experimental Cell Research]
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The authors describe that the stemness and differentiation potential of cancer stem cells were enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition and extracellular matrix remodeling to form the specific mechanism of vasculogenic mimicry.
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Wei, X., Chen, Y., Jiang, X., Peng, M., Liu, Y., Mo, Y., Ren, D., Hua, Y., Yu, B., Zhou, Y., Liao, Q., Wang, H., Xiang, B., Zhou, M., Li, X., Li, G., Li, Y., Xiong, W., & Zeng, Z. (2021). Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments. Molecular Cancer, 20(1), 7. https://doi.org/10.1186/s12943-020-01288-1 Cite
Scientists conducted a crossing study evaluating microvascular density, endothelial area, and Ki-67 proliferative index was reported for a series of formalin-fixed and paraffin-embedded tissue samples from 99 cat patients, affected by cat post-injection fibrosarcoma, by using a till ×400 magnification light microscopy.
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Patruno, R., Passantino, G., Laface, C., Tinelli, A., Zito, A., Ruggieri, R., Luposella, F., Gadaleta, P., Laforgia, M., Lacitignola, L., Ammendola, M., Ranieri, G., & Zizzo, N. (2021). Microvascular Density, Endothelial Area, and Ki-67 Proliferative Index Correlate Each Other in Cat Post-Injection Fibrosarcoma. Cells, 10(1), 31. https://doi.org/10.3390/cells10010031 Cite
Researchers characterized the expression of IL-36 members in human primary trophoblast cells and trophoblastic cell lines and upon treatment with bacterial and viral components.
[International Journal of Molecular Sciences]
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Murrieta-Coxca, J. M., Gutiérrez-Samudio, R. N., El-Shorafa, H. M., Groten, T., Rodríguez-Martínez, S., Cancino-Diaz, M. E., Cancino-Diaz, J. C., Favaro, R. R., Markert, U. R., & Morales-Prieto, D. M. (2021). Role of IL-36 Cytokines in the Regulation of Angiogenesis Potential of Trophoblast Cells. International Journal of Molecular Sciences, 22(1), 285. https://doi.org/10.3390/ijms22010285 Cite
The authors established a novel zebrafish transgenic line expressing eGFP under the control of part of the zebrafish Basic Leucine Zipper ATF‐Like Transcription Factor 3 (batf3) promoter. Spatiotemporal examination of Tg(batf3MIN:eGFP) transgenic fish revealed a typical lymphatic expression pattern, which does not perfectly recapitulate the expression pattern of existing lymphatic endothelial cell transgenic lines.
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Investigators demonstrated using an embryonic stem cell model that transient expression of the T-box transcription factor Eomesodermin governed hemogenic competency of extra-embryonic mesoderm.
[Nature Cell Biology]
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Harland, L. T. G., Simon, C. S., Senft, A. D., Costello, I., Greder, L., Imaz-Rosshandler, I., Göttgens, B., Marioni, J. C., Bikoff, E. K., Porcher, C., de Bruijn, M. F. T. R., & Robertson, E. J. (2021). The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors. Nature Cell Biology, 23(1), 61–74. https://doi.org/10.1038/s41556-020-00611-8 Cite
Adverum Biotechnologies, Inc. announced the completion of patient enrollment in the INFINITY Phase II trial to evaluate a single intravitreal injection of ADVM-022, for the treatment of diabetic macular edema.
[Adverum Biotechnologies, Inc.]
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Researchers hypothesized that modulation of oxygen conditions during uman amniotic fluid stem cell generation enriches soluble bioactive factors and confers enhanced regenerative and cardioprotective effects on cardiovascular cells.
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Kukumberg, M., Phermthai, T., Wichitwiengrat, S., Wang, X., Arjunan, S., Chong, S. Y., Fong, C.-Y., Wang, J.-W., Rufaihah, A. J., & Mattar, C. N. Z. (2021). Hypoxia-induced amniotic fluid stem cell secretome augments cardiomyocyte proliferation and enhances cardioprotective effects under hypoxic-ischemic conditions. Scientific Reports, 11(1), 163. https://doi.org/10.1038/s41598-020-80326-w Cite
Functional study demonstrated that exosomal LINC00161 derived from hepatocellular carcinoma (HCC)-cells were significantly associated with enhanced proliferation, migration, and angiogenesis in HUVECs in vitro, all of which were effectively inhibited when LINC00161 was sliced with shRNA in HCC-cells.
[Cancer Gene Therapy]
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You, L.-N., Tai, Q.-W., Xu, L., Hao, Y., Guo, W.-J., Zhang, Q., Tong, Q., Zhang, H., & Huang, W.-K. (2021). Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma. Cancer Gene Therapy, 1–18. https://doi.org/10.1038/s41417-020-00269-2 Cite