Ocular Therapeutix™ Announces First Patients Dosed in Phase II Clinical Trial of OTX-CSI for the Treatment of Dry Eye Disease

Ocular Therapeutix™, Inc. announced that it has dosed the first patients in its Phase II clinical trial of OTX-CSI for the treatment of dry eye disease.
[Ocular Therapeutix™, Inc.]
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Eyevensys Receives FDA Orphan Drug Designation for EYS611 for Treatment of Retinitis Pigmentosa

Eyevensys announced the FDA has granted an orphan-drug designation for EYS611 for the treatment of retinitis pigmentosa.
[Eyevensys]
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Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cell

Using three complementary mouse models of carotid artery injury, researchers demonstrated that both tamoxifen and estradiol accelerated endothelial healing, but only tamoxifen required the presence of the underlying medial smooth muscle cells.
[Circulation Research]
Zahreddine Rana, Davezac Morgane, Smirnova Natalia F, Buscato Mélissa, Lhuillier Emeline, Lupieri Adrien, Solinhac Romain, Vinel Alexia, Vessieres Emilie, Henrion Daniel, Renault Marie-Ange, Gadeau Alain-Pierre, Flouriot Gilles, Lenfant Francoise, Laffargue Muriel, Metivier Raphael, Arnal Jean-Francois, & Fontaine Coralie. (n.d.). Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cell. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317062 Cite
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Sulfated Glycans Engage the Ang–Tie Pathway to Regulate Vascular Development

Researchers demonstrated that heparan sulfate glycosaminoglycans (HS GAGs) regulate angiopoietin (Ang)–Tie signaling through direct interactions with both Ang ligands and Tie1 receptors. HS GAGs formed ternary complexes with Ang1 or Ang4 and Tie2 receptors, resulting in potentiation of endothelial survival signaling.
[Nature Chemical Biology]
Griffin, M. E., Sorum, A. W., Miller, G. M., Goddard, W. A., & Hsieh-Wilson, L. C. (2020). Sulfated glycans engage the Ang–Tie pathway to regulate vascular development. Nature Chemical Biology, 1–9. https://doi.org/10.1038/s41589-020-00657-7 Cite
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HIV Antivirals Affect Endothelial Activation and Endothelial-Platelet Crosstalk

HUVECs or human coronary artery endothelial cells were pre-treated with the antiretrovirals abacavir sulphate, tenofovir disoproxil fumarate or tenofovir alafenamide.
[Circulation Research]
Khawaja Akif A, Taylor Kirk A, Lovell Andrew O, Nelson Mark, Gazzard Brian, Boffito Marta, & Emerson Michael. (n.d.). HIV Antivirals Affect Endothelial Activation and Endothelial-Platelet Crosstalk. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316477 Cite
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Direct Extrusion of Individually Encapsulated Endothelial and Smooth Muscle Cells Mimicking Blood Vessel Structures and Vascular Native Cell Alignment

Prior to extrusion, the innermost cell encapsulating hydrogel was loaded with HUVECs, whereas the outer hydrogel was loaded with human aortic smooth muscle cells.
[Biofabrication]
Rué, E. B., Delgado, L. M., Gil, F. J., & Perez, R. A. (2020). Direct extrusion of individually encapsulated endothelial and smooth muscle cells mimicking blood vessel structures and vascular native cell alignment. Biofabrication. https://doi.org/10.1088/1758-5090/abbd27 Cite
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Electronic Blood Vessel

Investigators report an electronic blood vessel, with excellent biocompatibility, flexibility, mechanical strength, and degradability, that could enable in situ electrical stimulation and electroporation and exhibit excellent patency in a rabbit model.
[Matter]
Cheng, S., Hang, C., Ding, L., Jia, L., Tang, L., Mou, L., Qi, J., Dong, R., Zheng, W., Zhang, Y., & Jiang, X. (2020). Electronic Blood Vessel. Matter, 0(0). https://doi.org/10.1016/j.matt.2020.08.029 Cite
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Heterogeneity in VEGF Receptor-2 Mobility and Organization on the Endothelial Cell Surface Leads to Diverse Models of Activation by VEGF

Researchers found that surface VEGFR-2 could be mobile or exhibit restricted mobility and be monomeric or non-monomeric, with a complex interplay between the two.
[Cell Reports]
Rocha-Azevedo, B. da, Lee, S., Dasgupta, A., Vega, A. R., Oliveira, L. R. de, Kim, T., Kittisopikul, M., Malik, Z. A., & Jaqaman, K. (2020). Heterogeneity in VEGF Receptor-2 Mobility and Organization on the Endothelial Cell Surface Leads to Diverse Models of Activation by VEGF. Cell Reports, 32(13). https://doi.org/10.1016/j.celrep.2020.108187 Cite
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Tumoral Activation of TLR3–SLIT2 Axis in Endothelium Drives Metastasis

Scientists used mouse models of breast and lung cancer to investigate whether endothelial cells also have active ‘instructive’ roles in the dissemination of cancer.
[Nature]
Tavora, B., Mederer, T., Wessel, K. J., Ruffing, S., Sadjadi, M., Missmahl, M., Ostendorf, B. N., Liu, X., Kim, J.-Y., Olsen, O., Welm, A. L., Goodarzi, H., & Tavazoie, S. F. (2020). Tumoural activation of TLR3–SLIT2 axis in endothelium drives metastasis. Nature, 1–6. https://doi.org/10.1038/s41586-020-2774-y Cite
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Porphyromonas gingivalis Disrupts Vascular Endothelial Homeostasis in a TLR-NF-κB Axis Dependent Manner

To illuminate the effects and elucidate the mechanisms of P. gingivalis on endothelial structural integrity, investigators developed P. gingivalis infection models in vivo and in vitro.
[International Journal of Oral Science]
Xie, M., Tang, Q., Yu, S., Sun, J., Mei, F., Zhao, J., & Chen, L. (2020). Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner. International Journal of Oral Science, 12(1), 1–9. https://doi.org/10.1038/s41368-020-00096-z Cite
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Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis

The authors review recent findings describing new origins of lymphatic endothelial cells during embryonic development and discuss their relevance to cancer lymphangiogenesis.
[Frontiers in Physiology]
Gutierrez-Miranda, L., & Yaniv, K. (2020). Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis. Frontiers in Physiology, 11. https://doi.org/10.3389/fphys.2020.577584 Cite
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