Intravenous Injection of Cyclophilin a Realizes the Transient and Reversible Opening of Barrier of Neural Vasculature through Basigin in Endothelial Cells

Researchers demonstrated that the administration of cyclophilin A, a ligand of basigin which was expressed in barrier-forming endothelial cells, realized the artificial opening of blood–brain barrier.
[Scientific Reports]
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The Importance of Endothelial Protection: The Emerging Role of Defibrotide in Reversing Endothelial Injury and Its Sequelae

Further preclinical and clinical studies will explore defibrotide’s potential utility in a broader range of disorders resulting from endothelial cell activation and dysfunction.
[Bone Marrow Transplantation]
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Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis

Researchers identified integrin α5β1 as an EC receptor for AGGF1 and a novel AGGF1-mediated signaling pathway of α5β1-FAK-Src-AKT for angiogenesis.
[Arteriosclerosis Thrombosis & Vascular Biology]
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Exosomal OTULIN from M2 Macrophages Promotes the Recovery of Spinal Cord Injuries via Stimulating Wnt/β-Catenin Pathway-Mediated Vascular Regeneration

Researchers determined that M2-Exos could augment the angiogenic activities of spinal cord microvascular endothelial cells in vitro.
[Acta Biomaterialia]
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A Bioengineered Lymphatic Vessel Model for Studying Lymphatic Endothelial Cell-Cell Junction and Barrier Function

Scientists built a Lymphatic vessel-on-Chip by fabricating a microfluidic device that included a hollow microchannel embedded in 3D hydrogel.
[Microcirculation]
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Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension

In human endothelial cells, a striking correlation was observed between the degree of endothelial cell activation as reflected by intracellular adhesion molecule 1, isoLG-adduct accumulation and intracellular GAS6 levels.
[Circulation Research]
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Programmatic Introduction of Parenchymal Cell Types into Blood Vessel Organoids

Investigators presented a bottom-up engineering approach to building vascularized human tissue by combining genetic reprogramming with chemically directed organoid differentiation.
[Stem Cell Reports]
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Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors

The authors found that Fli1 governed vascular morphogenesis by regulating endothelial potential by inversely regulating endothelial versus myogenic programs in myogenic progenitor cells.
[Circulation Research]
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Chronic Exposure to Tramadol Induces Cardiac Inflammation and Endothelial Dysfunction in Mice

Tramadol upregulated the expression of oxidative stress and inflammatory markers in mice heart and aorta, whereas downregulated endothelial nitric oxide synthase enzyme expression.
[Scientific Reports]
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Derivation and Characterization of Endothelial Cells from Patients with Chronic Thromboembolic Pulmonary Hypertension

Scientists analyzed the endothelial function, molecular signature, and mitochondrial profile of chronic thromboembolic pulmonary hypertension (CTEPH)-derived endothelial cells to better understand the pathophysiological mechanisms of endothelial dysfunction behind CTEPH.
[Scientific Reports]
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The Development of Tumor Vascular Networks

To study and compare the development of vascular networks formed during angiogenesis and vasculogenic mimicry a number of in vitro assays were utilized.
[Communications Biology]
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