Zinc Drives Vasorelaxation by Acting in Sensory Nerves, Endothelium and Smooth Muscle

Researchers found that elevating cytoplasmic zinc using ionophores relaxed rat and human isolated blood vessels and caused hyperpolarization of smooth muscle membrane.
[Nature Communications]
Betrie, A. H., Brock, J. A., Harraz, O. F., Bush, A. I., He, G.-W., Nelson, M. T., Angus, J. A., Wright, C. E., & Ayton, S. (2021). Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle. Nature Communications, 12(1), 3296. https://doi.org/10.1038/s41467-021-23198-6 Cite
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3D Cell Culture Using a Clinostat Reproduces Microgravity-Induced Skin Changes

Investigators showed that under time-averaged simulated microgravity, the thickness of the endothelial cell arrangement increased by up to 59.75%, indicating skin irritation due to vasodilation, and that the diameter of keratinocytes and fibroblast co-cultured spheroids decreased by 6.66%, representing skin thinning.
[npj Microgravity]
Choi, D. H., Jeon, B., Lim, M. H., Lee, D. H., Ye, S.-K., Jeong, S.-Y., & Kim, S. (2021). 3D cell culture using a clinostat reproduces microgravity-induced skin changes. Npj Microgravity, 7(1), 1–7. https://doi.org/10.1038/s41526-021-00148-6 Cite
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Heparan Sulfate Proteoglycan Glypican-1 and PECAM-1 Cooperate in Shear-Induced Endothelial Nitric Oxide Production

Atomic force microscopy pulling was used to apply force to glypican-1 and PECAM-1 on the surface of human umbilical vein endothelial cells and nitric oxide was measured using a fluorescent reporter dye.
[Scientific Reports]
Bartosch, A. M. W., Mathews, R., Mahmoud, M. M., Cancel, L. M., Haq, Z. S., & Tarbell, J. M. (2021). Heparan sulfate proteoglycan glypican-1 and PECAM-1 cooperate in shear-induced endothelial nitric oxide production. Scientific Reports, 11(1), 11386. https://doi.org/10.1038/s41598-021-90941-w Cite
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Decellularized Dermis Extracellular Matrix Alloderm Mechanically Strengthens Biological Engineered Tunica Adventitia-Based Blood Vessels

Researchers evaluated the commercially-available decellularized skin dermis ECM Alloderm for efficacy in providing structure to biological engineered blood vessels.
[Scientific Reports]
Patel, B., Wonski, B. T., Saliganan, D. M., Rteil, A., Kabbani, L. S., & Lam, M. T. (2021). Decellularized dermis extracellular matrix alloderm mechanically strengthens biological engineered tunica adventitia-based blood vessels. Scientific Reports, 11(1), 11384. https://doi.org/10.1038/s41598-021-91005-9 Cite
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Omeros Announces Preliminary Results from Additional Critically Ill COVID-19 Patients Treated with Narsoplimab

Omeros Corporation announced preliminary results from the second cohort of critically ill COVID-19 patients treated with narsoplimab in Bergamo, Italy.
[Omeros Corporation]
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Nuclear Exosome HMGB3 Secreted by Nasopharyngeal Carcinoma Cells Promotes Tumor Metastasis by Inducing Angiogenesis

Researchers explored for the first time the function of nuclear exosomes HMGB3 in tumor angiogenesis involved in nasopharyngeal carcinoma metastasis using a series of in vitro experiments with nasopharyngeal carcinoma cell lines and clinical specimens.
[Cell Death & Disease]
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Venous Malformation Vessels Are Improperly Specified and Hyperproliferative

Scientists characterized venous malformation endothelial and mural cell expression by performing a comprehensive expression analysis of venous malformation vasculature.
[PLOS ONE]
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Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

The authors review and compare five bioactive elements with respect to their effect on the angiogenic behavior of endothelial cells when incorporated on the surface of biomaterials.
[Advanced Healthcare Materials]
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Characterization of the Heterogeneity of Endothelial Cells in Bleomycin-Induced Lung Fibrosis Using Single-Cell RNA Sequencing

Scientists performed single-cell RNA sequencing to characterize the heterogeneity of endothelial cells in bleomycin-induced lung fibrosis in rats.
[Angiogenesis]
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Systemic Metastasis-Targeted Nanotherapeutic Reinforces Tumor Surgical Resection and Chemotherapy

Investigators designed a systemic metastasis-targeted nanotherapeutic (H@CaPP) to hinder the multiple steps of tumor metastasis. H@CaPP efficiently inhibited tumor metastasis and prolonged overall survival of 4T1 mammary tumor-bearing mice.
[Nature Communications]
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Endothelial Tpl2 Regulates Vascular Barrier Function via JNK-Mediated Degradation of Claudin-5 Promoting Neuroinflammation or Tumor Metastasis

Using tissue-specific genetic ablation in endothelial cells, scientists investigated in vivo the role of tumor progression locus 2 (Tpl2), a mitogen-activated protein kinase kinase kinase member with pleiotropic effects in inflammation and cancer.
[Cell Reports]
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