ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

The authors performed an in silico study of ADAMTS1 and endothelial markers in human gliomas, providing the basis to further assess these molecules in several primary glioblastoma-initiating cells and established glioblastoma cells with the ability to acquire an endothelial-like phenotype.
[Biomolecules]
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Carbon Nano-Onion-Mediated Dual Targeting of P-Selectin and P-Glycoprotein to Overcome Cancer Drug Resistance

Investigators report a fucoidan-decorated silica-carbon nano-onion hybrid nanoparticle that targeted tumor vasculature to specifically release P-glycoprotein inhibitor and anticancer drug into tumor cells.
[Nature Communications]
Wang, H., Liang, Y., Yin, Y., Zhang, J., Su, W., White, A. M., Bin Jiang, Xu, J., Zhang, Y., Stewart, S., Lu, X., & He, X. (2021). Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance. Nature Communications, 12(1), 312. https://doi.org/10.1038/s41467-020-20588-0 Cite
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Endothelial Cells Control Vascular Smooth Muscle Cell Cholesterol Levels by Regulating 24-Dehydrocholesterol Reductase Expression

The authors investigated changes of the vascular smooth muscle cell (VSMC) transcriptome by utilizing 3D human vascular organoids organized as a core of VSMCs enclosed by a monolayer of endothelial cells.
[Experimental Cell Research]
Kohlhaas, J., Jäger, M., Lust, L., De La Torre, C., Hecker, M., & Korff, T. (2021). Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Experimental Cell Research, 112446. https://doi.org/10.1016/j.yexcr.2020.112446 Cite
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Mechanisms of Vasculogenic Mimicry in Hypoxic Tumor Microenvironments

The authors describe that the stemness and differentiation potential of cancer stem cells were enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition and extracellular matrix remodeling to form the specific mechanism of vasculogenic mimicry.
[Molecular Cancer]
Wei, X., Chen, Y., Jiang, X., Peng, M., Liu, Y., Mo, Y., Ren, D., Hua, Y., Yu, B., Zhou, Y., Liao, Q., Wang, H., Xiang, B., Zhou, M., Li, X., Li, G., Li, Y., Xiong, W., & Zeng, Z. (2021). Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments. Molecular Cancer, 20(1), 7. https://doi.org/10.1186/s12943-020-01288-1 Cite
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Microvascular Density, Endothelial Area, and Ki-67 Proliferative Index Correlate Each Other in Cat Post-Injection Fibrosarcoma

Scientists conducted a crossing study evaluating microvascular density, endothelial area, and Ki-67 proliferative index was reported for a series of formalin-fixed and paraffin-embedded tissue samples from 99 cat patients, affected by cat post-injection fibrosarcoma, by using a till ×400 magnification light microscopy.
[Cells]
Patruno, R., Passantino, G., Laface, C., Tinelli, A., Zito, A., Ruggieri, R., Luposella, F., Gadaleta, P., Laforgia, M., Lacitignola, L., Ammendola, M., Ranieri, G., & Zizzo, N. (2021). Microvascular Density, Endothelial Area, and Ki-67 Proliferative Index Correlate Each Other in Cat Post-Injection Fibrosarcoma. Cells, 10(1), 31. https://doi.org/10.3390/cells10010031 Cite
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Role of IL-36 Cytokines in the Regulation of Angiogenesis Potential of Trophoblast Cells

Researchers characterized the expression of IL-36 members in human primary trophoblast cells and trophoblastic cell lines and upon treatment with bacterial and viral components.
[International Journal of Molecular Sciences]
Murrieta-Coxca, J. M., Gutiérrez-Samudio, R. N., El-Shorafa, H. M., Groten, T., Rodríguez-Martínez, S., Cancino-Diaz, M. E., Cancino-Diaz, J. C., Favaro, R. R., Markert, U. R., & Morales-Prieto, D. M. (2021). Role of IL-36 Cytokines in the Regulation of Angiogenesis Potential of Trophoblast Cells. International Journal of Molecular Sciences, 22(1), 285. https://doi.org/10.3390/ijms22010285 Cite
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A New Reporter Zebrafish Line Unveils Heterogeneity among Lymphatic Endothelial Cells during Development

The authors established a novel zebrafish transgenic line expressing eGFP under the control of part of the zebrafish Basic Leucine Zipper ATF‐Like Transcription Factor 3 (batf3) promoter. Spatiotemporal examination of Tg(batf3MIN:eGFP) transgenic fish revealed a typical lymphatic expression pattern, which does not perfectly recapitulate the expression pattern of existing lymphatic endothelial cell transgenic lines.
[Developmental Dynamics]
Frétaud, M., Khoa, N. D., Houel, A., Lunazzi, A., Boudinot, P., & Langevin, C. (n.d.). A new reporter zebrafish line unveils heterogeneity among lymphatic endothelial cells during development. Developmental Dynamics, n/a(n/a). https://doi.org/https://doi.org/10.1002/dvdy.286 Cite
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The T-Box Transcription Factor Eomesodermin Governs Hemogenic Competence of Yolk Sac Mesodermal Progenitors

Investigators demonstrated using an embryonic stem cell model that transient expression of the T-box transcription factor Eomesodermin governed hemogenic competency of extra-embryonic mesoderm.
[Nature Cell Biology]
Harland, L. T. G., Simon, C. S., Senft, A. D., Costello, I., Greder, L., Imaz-Rosshandler, I., Göttgens, B., Marioni, J. C., Bikoff, E. K., Porcher, C., de Bruijn, M. F. T. R., & Robertson, E. J. (2021). The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors. Nature Cell Biology, 23(1), 61–74. https://doi.org/10.1038/s41556-020-00611-8 Cite
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Adverum Biotechnologies Completes Patient Enrollment for INFINITY Phase II Trial of ADVM-022 in DME and Provides 2021 Business Outlook

Adverum Biotechnologies, Inc. announced the completion of patient enrollment in the INFINITY Phase II trial to evaluate a single intravitreal injection of ADVM-022, for the treatment of diabetic macular edema.
[Adverum Biotechnologies, Inc.]
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Hypoxia-Induced Amniotic Fluid Stem Cell Secretome Augments Cardiomyocyte Proliferation and Enhances Cardioprotective Effects under Hypoxic-Ischemic Conditions

Researchers hypothesized that modulation of oxygen conditions during uman amniotic fluid stem cell generation enriches soluble bioactive factors and confers enhanced regenerative and cardioprotective effects on cardiovascular cells.
[Scientific Reports]
Kukumberg, M., Phermthai, T., Wichitwiengrat, S., Wang, X., Arjunan, S., Chong, S. Y., Fong, C.-Y., Wang, J.-W., Rufaihah, A. J., & Mattar, C. N. Z. (2021). Hypoxia-induced amniotic fluid stem cell secretome augments cardiomyocyte proliferation and enhances cardioprotective effects under hypoxic-ischemic conditions. Scientific Reports, 11(1), 163. https://doi.org/10.1038/s41598-020-80326-w Cite
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Exosomal LINC00161 Promotes Angiogenesis and Metastasis via Regulating miR-590-3p/ROCK Axis in Hepatocellular Carcinoma

Functional study demonstrated that exosomal LINC00161 derived from hepatocellular carcinoma (HCC)-cells were significantly associated with enhanced proliferation, migration, and angiogenesis in HUVECs in vitro, all of which were effectively inhibited when LINC00161 was sliced with shRNA in HCC-cells.
[Cancer Gene Therapy]
You, L.-N., Tai, Q.-W., Xu, L., Hao, Y., Guo, W.-J., Zhang, Q., Tong, Q., Zhang, H., & Huang, W.-K. (2021). Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma. Cancer Gene Therapy, 1–18. https://doi.org/10.1038/s41417-020-00269-2 Cite
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