Transcriptomic Comparison of Human and Mouse Brain Microvessels

Investigators performed RNA sequencing on brain microvessel preparations isolated from snap-frozen human and mouse tissues by laser capture microdissection
[Scientific Reports]
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SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45 Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome

Investigators demonstrated for the first time that ACE2 and the entry-facilitating transmembrane protease TMPRSS2 were expressed on very small CD133+CD34+LinCD45 cells in human umbilical cord blood, which could be specified into functional hematopoietic stem cells and endothelial progenitor cells.
[Stem Cell Reviews and Reports]
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Human Endothelial Colony-Forming Cells in Regenerative Therapy: A Systematic Review of Controlled Preclinical Animal Studies

Endothelial colony‐forming cells hold significant promise as candidates for regenerative therapy of vascular injury. Existing studies remain largely preclinical and exhibit marked design heterogeneity
[Stem Cells Translational Medicine]
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Beneficial Effects of IL-4 and IL-6 on Rat Neonatal Target Cardiac Cells

Scientists found that M2 compared to M1 macrophage-conditioned media upregulated neonatal cardiomyocyte proliferation, suppressed myofibroblast-induced differentiation and stimulated endothelial cell tube formation.
[Scientific Reports]
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Intrinsic Transcriptomic Sex Differences in Human Endothelial Cells at Birth and in Adults Are Associated with Coronary Artery Disease Targets

The authors analyzed endothelial cell (EC) gene expression data from boy–girl twins at birth and in non-twin adults to detect sex differences at different stages of life, and show that 14–25% of the EC transcriptome was sex-biased.
[Scientific Reports]
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Clinical Trials Rebound After COVID-19 Crash, but Can Enrollment Gains Continue?

For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
[ScienceInsider]
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Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]
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Epigenetics in Modulating Immune Functions of Stromal and Immune Cells in the Tumor Microenvironment

The authors review recent studies demonstrating how specific epigenetic mechanisms drive aspects of stromal and immune cell differentiation with implications for the development of solid tumor therapeutics, focusing on the pancreatic ductal adenocarcinoma tumor microenvironment as a representative of solid tumors.
[Cellular & Molecular Immunology]
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Impact of Local Allo-Immunity and Recipient Cells in Transplant Arteriosclerosis

Investigators report the transcriptional profiling of 11,868 cells in a mouse model of transplant arteriosclerosis by single-cell RNA sequencing.
[Circulation Research]
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The Histone Lysine Methyltransferase SETD8 Regulates Angiogenesis through HES-1 in Human Umbilical Vein Endothelial Cells

The authors showed that BVT-948-mediated SETD8 inhibition in HUVECs resulted in an inhibition of angiogenesis. Inhibition of SETD8 not only inhibited angiogenesis but also disrupted actin stress fiber formation and induced cell cycle arrest at S phase.
[Scientific Reports]
Choi, D. K., Kim, Y. K., Park, S. W., Lee, H., Lee, S., Kim, S. A., … Yu, J. H. (2020). The histone lysine methyltransferase SETD8 regulates angiogenesis through HES-1 in human umbilical vein endothelial cells. Scientific Reports, 10(1), 12089. https://doi.org/10.1038/s41598-020-69103-x Cite
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Reduced Intracellular Chloride Concentration Impairs Angiogenesis by Inhibiting Oxidative Stress-Mediated VEGFR2 Activation

Investigators showed that reduction of [Cl−]i inhibited HUVEC proliferation, migration, cytoskeleton reorganization, tube formation, and subsequently suppressed angiogenesis under basal condition, and VEGF stimulation or hypoxia treatment.
[Acta Pharmacologica Sinica]
Li, K., Liu, Y., Lv, X., Lin, Z., Zhang, T., Zhang, F., Guo, J., Hong, Y., Liu, X., Lin, X., Zhou, J., Wu, Q., Liang, S., & Shang, J. (2020). Reduced intracellular chloride concentration impairs angiogenesis by inhibiting oxidative stress-mediated VEGFR2 activation. Acta Pharmacologica Sinica, 1–13. https://doi.org/10.1038/s41401-020-0458-7 Cite
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Mitochondrial Respiration Controls Neoangiogenesis during Wound Healing and Tumor Growth

Scienitsts assessed the impact of mitochondrial bioenergetics on neovascularisation, by deleting cox10 gene encoding an assembly factor of cytochrome c oxidase specifically in mouse endothelial cells providing a model for vasculature-restricted respiratory deficiency.
[Nature Communications]
Schiffmann, L. M., Werthenbach, J. P., Heintges-Kleinhofer, F., Seeger, J. M., Fritsch, M., Günther, S. D., Willenborg, S., Brodesser, S., Lucas, C., Jüngst, C., Albert, M. C., Schorn, F., Witt, A., Moraes, C. T., Bruns, C. J., Pasparakis, M., Krönke, M., Eming, S. A., Coutelle, O., & Kashkar, H. (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nature Communications, 11(1), 3653. https://doi.org/10.1038/s41467-020-17472-2 Cite
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