Researchers found that elevating cytoplasmic zinc using ionophores relaxed rat and human isolated blood vessels and caused hyperpolarization of smooth muscle membrane.
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Betrie, A. H., Brock, J. A., Harraz, O. F., Bush, A. I., He, G.-W., Nelson, M. T., Angus, J. A., Wright, C. E., & Ayton, S. (2021). Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle. Nature Communications, 12(1), 3296. https://doi.org/10.1038/s41467-021-23198-6 Cite
Investigators showed that under time-averaged simulated microgravity, the thickness of the endothelial cell arrangement increased by up to 59.75%, indicating skin irritation due to vasodilation, and that the diameter of keratinocytes and fibroblast co-cultured spheroids decreased by 6.66%, representing skin thinning.
Atomic force microscopy pulling was used to apply force to glypican-1 and PECAM-1 on the surface of human umbilical vein endothelial cells and nitric oxide was measured using a fluorescent reporter dye.
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Researchers evaluated the commercially-available decellularized skin dermis ECM Alloderm for efficacy in providing structure to biological engineered blood vessels.
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Patel, B., Wonski, B. T., Saliganan, D. M., Rteil, A., Kabbani, L. S., & Lam, M. T. (2021). Decellularized dermis extracellular matrix alloderm mechanically strengthens biological engineered tunica adventitia-based blood vessels. Scientific Reports, 11(1), 11384. https://doi.org/10.1038/s41598-021-91005-9 Cite
Omeros Corporation announced preliminary results from the second cohort of critically ill COVID-19 patients treated with narsoplimab in Bergamo, Italy.
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Researchers explored for the first time the function of nuclear exosomes HMGB3 in tumor angiogenesis involved in nasopharyngeal carcinoma metastasis using a series of in vitro experiments with nasopharyngeal carcinoma cell lines and clinical specimens.
[Cell Death & Disease]
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Scientists characterized venous malformation endothelial and mural cell expression by performing a comprehensive expression analysis of venous malformation vasculature.
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The authors review and compare five bioactive elements with respect to their effect on the angiogenic behavior of endothelial cells when incorporated on the surface of biomaterials.
[Advanced Healthcare Materials]
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Scientists performed single-cell RNA sequencing to characterize the heterogeneity of endothelial cells in bleomycin-induced lung fibrosis in rats.
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Investigators designed a systemic metastasis-targeted nanotherapeutic (H@CaPP) to hinder the multiple steps of tumor metastasis. H@CaPP efficiently inhibited tumor metastasis and prolonged overall survival of 4T1 mammary tumor-bearing mice.
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Using tissue-specific genetic ablation in endothelial cells, scientists investigated in vivo the role of tumor progression locus 2 (Tpl2), a mitogen-activated protein kinase kinase kinase member with pleiotropic effects in inflammation and cancer.
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