Control of Endothelial Quiescence by FOXO-Regulated Metabolites

The authors showed that the metabolite S-2-hydroxyglutarate played a crucial role in the regulation of endothelial quiescence
[Nature Cell Biology]
Andrade, J., Shi, C., Costa, A. S. H., Choi, J., Kim, J., Doddaballapur, A., Sugino, T., Ong, Y. T., Castro, M., Zimmermann, B., Kaulich, M., Guenther, S., Wilhelm, K., Kubota, Y., Braun, T., Koh, G. Y., Grosso, A. R., Frezza, C., & Potente, M. (2021). Control of endothelial quiescence by FOXO-regulated metabolites. Nature Cell Biology, 1–11. https://doi.org/10.1038/s41556-021-00637-6 Cite
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Endothelial Wnts Control Mammary Epithelial Patterning via Fibroblast Signaling

To enable cell-type-specific gene manipulation in vitro, scientists establish an organoid system via coculture of endothelial cells (ECs), fibroblasts, and mammary epithelial cells.
[Cell Reports]
Wang, J., Song, W., Yang, R., Li, C., Wu, T., Dong, X. B., Zhou, B., Guo, X., Chen, J., Liu, Z., Yu, Q. C., Li, W., Fu, J., & Zeng, Y. A. (2021). Endothelial Wnts control mammary epithelial patterning via fibroblast signaling. Cell Reports, 34(13). https://doi.org/10.1016/j.celrep.2021.108897 Cite
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Contribution of Cell Death Signaling to Blood Vessel Formation

Scientists summarize the current knowledge on the role of the cell death signaling machinery with a focus on the apoptosis and necroptosis signaling pathways during blood vessel formation in development and pathology.
[Cellular and Molecular Life Sciences]
Tisch, N., & Ruiz de Almodóvar, C. (2021). Contribution of cell death signaling to blood vessel formation. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-020-03738-x Cite
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A Single-Cell Resolution Developmental Atlas of Hematopoietic Stem and Progenitor Cell Expansion in Zebrafish

Using single-cell RNA-sequencing, researchers deciphered a dynamic atlas covering 28,777 cells and nine major cell types of zebrafish caudal hematopoietic tissue.
[Proceedings of the National Academy of Sciences of the United States of America]
Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.-D. J., & Liu, F. (2021). A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences, 118(14). https://doi.org/10.1073/pnas.2015748118 Cite
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The Migratory Pathways of the Cells That Form the Endocardium, Dorsal Aortae, and Head Vasculature in the Mouse Embryo

Investigators describe the pathways that cells follow to form the primary embryonic circulatory system in the mouse embryo.
[BMC Developmental Biology]
Collart, C., Ciccarelli, A., Ivanovitch, K., Rosewell, I., Kumar, S., Kelly, G., Edwards, A., & Smith, J. C. (2021). The migratory pathways of the cells that form the endocardium, dorsal aortae, and head vasculature in the mouse embryo. BMC Developmental Biology, 21(1), 8. https://doi.org/10.1186/s12861-021-00239-3 Cite
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First Blood: The Endothelial Origins of Hematopoietic Progenitors

Sequential waves of definitive hematopoiesis arise from yolk sac and intembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition.
[Angiogenesis]
Canu, G., & Ruhrberg, C. (2021). First blood: the endothelial origins of hematopoietic progenitors. Angiogenesis. https://doi.org/10.1007/s10456-021-09783-9 Cite
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VEGFR-1/Flt-1 Inhibition Increases Angiogenesis and Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy

Researchers developed monoclonal antibodies that bind to the VEGF receptor VEGFR-1 and its soluble splice variant isoform leading to increased levels of free VEGF and proangiogenic signaling.
[Molecular Therapy-Methods & Clinical Development]
Bosco, J., Zhou, Z., Gabriëls, S., Verma, M., Liu, N., Miller, B. K., Gu, S., Lundberg, D. M., Huang, Y., Brown, E., Josiah, S., Meiyappan, M., Traylor, M. J., Chen, N., Asakura, A., Jonge, N. D., Blanchetot, C., Haard, H. de, Duffy, H. S., & Keefe, D. (2021). VEGFR-1/Flt-1 Inhibition Increases Angiogenesis and Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2021.03.013 Cite
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The CREB/KMT5A Complex Regulates PTP1B to Modulate High Glucose-Induced Endothelial Inflammatory Factor Levels in Diabetic Nephropathy

The authors hypothesized that cAMP response element-binding protein (CREB) associated with KMT5A to modulate PTP1B expression, thus contributing to high glucose-mediated glomerular endothelial inflammation.
[Cell Death & Disease]
Huang, T., Li, X., Wang, F., Lu, L., Hou, W., Zhu, M., & Miao, C. (2021). The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03629-4 Cite
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Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells

HUVECs and human lung microvascular endothelial cells incubated with human sickle cell plasma had significant increases in pro-inflammatory IL-8, IL-6, and soluble VCAM-1 secretion compared to endothelial cells incubated with normal plasma.
[Frontiers in Immunology]
Zhang, P., Nguyen, J., Abdulla, F., Nelson, A. T., Beckman, J. D., Vercellotti, G. M., & Belcher, J. D. (2021). Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.632709 Cite
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Loss of Bone Morphogenetic Protein-Binding Endothelial Regulator Causes Insulin Resistance

Both global and endothelial cell-specific inducible knockout of bone morphogenetic protein-binding endothelial regulator cause hyperinsulinemia, glucose intolerance and insulin resistance without increasing inflammation in metabolic tissues in mice.
[Nature Communications]
Mao, H., Li, L., Fan, Q., Angelini, A., Saha, P. K., Wu, H., Ballantyne, C. M., Hartig, S. M., Xie, L., & Pi, X. (2021). Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. Nature Communications, 12(1), 1927. https://doi.org/10.1038/s41467-021-22130-2 Cite
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Increased Angiogenesis and Migration of Dermal Microvascular Endothelial Cells from Patients with Psoriasis

Researchers isolated human dermal microvascular endothelial cells (HDMECs) from the skin of ten patients with psoriasis and ten healthy subjects and compared angiogenesis, proliferation, migration and cell metabolism between psoriatic HDMECs and normal HDMECs.
[Experimental Dermatology]
Li, J., Hou, H., Zhou, L., Wang, J., Liang, J., Li, J., Hou, R., Niu, X., Yin, G., Li, X., & Zhang, K. (n.d.). Increased angiogenesis and migration of dermal microvascular endothelial cells from patients with psoriasis. Experimental Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/exd.14329 Cite
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