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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Pseudomonas aeruginosa Breaches Respiratory Epithelia Through Goblet Cell Invasion in a Microtissue Model
[Nature Microbiology] Using infection of human respiratory epithelium organoids, researchers observed that P. aeruginosa colonization of apical surfaces was promoted by cyclic di-GMP-dependent asymmetric division.
Exploring Conformational Landscapes and Binding Mechanisms of Convergent Evolution for the SARS-CoV-2 Spike Omicron Variant Complexes with the ACE2 Receptor Using AlphaFold2-Based Structural Ensembles...
[Physical Chemistry Chemical Physics] Researchers combined AlphaFold-based approaches for atomistic modeling of multiple protein states and microsecond molecular simulations to accurately characterize conformational ensembles evolution and binding mechanisms of convergent evolution for the SARS-CoV-2 spike Omicron variants BA.1, BA.2, BA.2.75, BA.3, BA.4/BA.5 and BQ.1.1.
Choroid Plexus Defects in Down Syndrome Brain Organoids Enhance Neurotropism of SARS-CoV-2
[Science Advances] Scientists demonstrated that the choroid plexus (ChP)-like epithelium facilitated infection and replication of SARS-CoV-2 in cortical neurons and that this is increased in Down syndrome (DS) established brain organoids from DS and isogenic euploid iPSC that consist of a core of functional cortical neurons surrounded by a functional ChP-like epithelium.
Phase I, Randomized, Rater and Participant Blinded Placebo-Controlled Study of the Safety, Reactogenicity, Tolerability and Immunogenicity of H1N1 Influenza Vaccine Delivered by VX-103 (a...
[PLOS One] Investigators described safety, reactogenicity, tolerability and immunogenicity for MIMIX microneedle array patch vaccination against influenza.
The Impact of Plasmodium-Driven Immunoregulatory Networks on Immunity to Malaria
[Nature Reviews Immunology] The authors discuss the specific cellular mechanisms of immunoregulatory networks that develop during malaria, with a focus on knowledge gained from human studies and studies that involve the main malaria parasite to affect humans, Plasmodium falciparum.
Drug-Resistant Infections More Likely to Strike Women, Says WHO
[Nature] Women might be more likely to develop drug-resistant infections than men — an under-recognized aspect of the growing threat of antimicrobial resistance, according to a global review led by the World Health Organization (WHO).
A Little-Known Virus on the Rise in South America Could Overwhelm Health Systems
[Science] A little-known pathogen named the Oropouche virus is on the move in South America, alarming scientists and public health experts. Brazil has reported 5530 cases so far this year, compared with 836 in all of 2023.
Cellular and Humoral Immunogenicity against SARS-CoV-2 Vaccination or Infection Is Associated with the Memory Phenotype of T- and B-lymphocytes in Adult Allogeneic Hematopoietic Cell...
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[International Journal of Hematology] Scientists conducted a cross-sectional study to evaluate cellular and humoral immunogenicity against SARS-CoV-2 vaccination or infection and examined how lymphocyte subpopulations in peripheral blood correlate with cellular and humoral immunogenicity in adult allogeneic hematopoietic cell transplantation recipients.
The 5′-Terminal Stem–Loop RNA Element of SARS-CoV-2 Features Highly Dynamic Structural Elements That Are Sensitive to Differences in Cellular pH
[Nucleic Acids Research] The authors presented the nuclear magnetic resonance spectroscopy solution structure of the 5′-terminal stem loop 5_SL1 of the SARS-CoV-2 genome.
Multivalent mRNA-DTP Vaccines Are Immunogenic and Provide Protection from Bordetella pertussis Challenge in Mice
[NPJ Vaccines] Immunogenicity and challenge models were used to evaluate the mRNA platform with multivalent vaccine formulations targeting both B. pertussis antigens and diphtheria and tetanus toxoids.
Antiviral Activity of Pimecrolimus against Dengue Virus Type 2 Infection In Vitro and In Vivo
[Scientific Reports] Researchers identified antiviral drugs against DENV type 2 infections and selected pimecrolimus as a potential antiviral drug candidate.
Differential Responses of SARS-CoV-2 Variants to Environmental Drivers during Their Selective Sweeps
[Scientific Reports] Investigators leveraged genetic data on the transmission of three variants of SARS-CoV-2 throughout England, to unpick the roles that climate and public-health interventions play in the circulation of this virus.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
