Scientists demonstrated that both diabetic foot ulcers and venous leg ulcers exhibited global deregulation of cytoskeletal organization in genomic comparison to normal skin and acute wounds.
[Communications Biology]
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Jozic, I., Abujamra, B. A., Elliott, M. H., Wikramanayake, T. C., Marjanovic, J., Stone, R. C., Head, C. R., Pastar, I., Kirsner, R. S., Andreopoulos, F. M., Musi, J. P., & Tomic-Canic, M. (2021). Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-021-02298-5 Cite