Essential Contribution of Macrophage Tie2 Signaling in a Murine Model of Laser-Induced Choroidal Neovascularization

Scientists observed that Tie2-expressing macrophages prevented apoptosis of b.End3 cells, but promoted their migration, proliferation and tube formation via VEGF, extracellular signal-regulated kinase and v-akt murine thymoma viral oncogene-dependent signaling pathways.