Inhibition of Hypoxia-Induced Mucin 1 Alters the Proteomic Composition of Human Osteoblast-Produced Extracellular Matrix, Leading to Reduced Osteogenic and Angiogenic Potential

Investigators assessed the Mucin 1-mediated effect of hypoxia on the proteomic composition of human osteoblast-derived extracellular matrices (ECM) and characterized their osteogenic and angiogenic potentials in the produced ECMs.