Role of mTORC1 Activity during Early Retinal Development and Lamination in Human-Induced Pluripotent Stem Cell-Derived Retinal Organoids

Using hiPSC-derived retinal organoids, researchers identified the time-dependent role of mammalian target of rapamycin complex 1 (mTORC1) in retinal development, specifically in retinal ganglion cell differentiation and the retinal lamination process, during the early stages of retinal organoid development.