Modulation of Immune Checkpoints by Chemotherapy in Human Colorectal Liver Metastases

By
Justin.choi
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Scientists investigated the impact of chemotherapy on the tumor immune microenvironment. They treated human liver metastases slices with 5-fluorouracil plus either irinotecan or oxaliplatin, then performed single-cell transcriptome analyses.
[Cell Reports Medicine]
Jabbari, N., Kenerson, H. L., Lausted, C., Yan, X., Meng, C., Sullivan, K. M., Baloni, P., Bergey, D., Pillarisetty, V. G., Hood, L. E., Yeung, R. S., & Tian, Q. (2020). Modulation of Immune Checkpoints by Chemotherapy in Human Colorectal Liver Metastases. Cell Reports Medicine, 1(9). https://doi.org/10.1016/j.xcrm.2020.100160 Cite
Abstract